Medicine

Advancing ASO therapies from development to application

.Contending interests.R.S., M.S., H.G. as well as A.A.R. are actually planners of the 1M1M effort. H.G. as well as A.A.R. are board of directors participants as well as R.S., M.S. as well as A.A.R. are participants of the clinical consultatory board of N1C. A.A.R. reveals job by LUMC, which has licenses on exon-skipping technology, several of which has actually been licensed to BioMarin and also subsequently sublicensed to Sarepta. As co-inventor of a number of these licenses, A.A.R. was actually qualified to a reveal of royalties. A.A.R. even further makes known serving as ad hoc expert for PTC Therapies, Sarepta Therapies, Regenxbio, Dyne Rehabs, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco and Astra Zeneca. In the past 5 years, A.A.R. likewise performed speaking to for Alpha Anomeric. A.A.R. also reports registration of the scientific boards of advisers of Eisai, Hybridize Therapeutics, Silence Therapies, Sarepta Therapeutics, Sapreme and also Mitorx. Over the last 5 years, A.A.R. was also a medical advisory board participant for ProQR. Pay for A.A.R. u00e2 s consulting as well as encouraging tasks is paid out to LUMC. Previously 5 years, LUMC additionally acquired speaker honoraria from PTC Therapies, Alnylam Netherlands, Italfarmaco and Pfizer and cashing for contract analysis coming from Sapreme, Eisai, Galapagos, Synaffix as well as Alpha Anomeric. Job funding is gotten coming from Sarepta Therapies as well as Entrada via unrestricted grants. H.G. has absolutely nothing to make known relative to the topics dealt with in this document. In the past 5 years, he has actually likewise obtained consultancy honoraria coming from UCB. M.S. obtained working as a consultant gratuity coming from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly and also Solaxa before 5 years, all irrelevant to the present composition. R.S. has nothing at all to make known relative to the subject matters covered within this document. She has actually gotten audio speaker and/or consultancy gratuity or even financing contributions from Abbvie, Bial, STADA and also Everpharma in the past 5 years.